Expression of microRNA-324-5p in hepatocellular carcinoma based on the Cancer Genome Atlas (TCGA) database and analysis of prognosis risk factor

Autor: WU Chengxiao, FANG Jie, ZHOU Jichuan, XIAO Yongsheng, ZHANG Xiaoguang
Jazyk: čínština
Rok vydání: 2021
Předmět:
Zdroj: Waike lilun yu shijian, Vol 26, Iss 03, Pp 249-253 (2021)
Druh dokumentu: article
ISSN: 1007-9610
DOI: 10.16139/j.1007-9610.2021.03.015
Popis: Objective To study the expression of microRNA-324-5p (miR-324-5p) in hepatocellular carcinoma (HCC) and the prognosis risk factor in patients with HCC. Methods MiRNA expression database in tissue of both tumor and normal liver combined with clinical data of HCC patients were collected from The Cancer Genome Atlas (TCGA) database. Relationship between miR-324-5p expression and pathological features was analyzed. Relation of miR-324-5p expression to prognosis of the patients was analyzed through survival curve. Univariate and multivariate Cox regression models were used to analyze the risk factors related to HCC. Results The expressions of miR-324-5p in HCC were higher than those in normal tissues(P
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