Relevance of vitamin D deficiency in patients with chronic autoimmune atrophic gastritis: a prospective study

Autor: Sara Massironi, Federica Cavalcoli, Alessandra Zilli, Alessandro Del Gobbo, Clorinda Ciafardini, Susanna Bernasconi, Irene Felicetta, Dario Conte, Maddalena Peracchi
Jazyk: angličtina
Rok vydání: 2018
Předmět:
Zdroj: BMC Gastroenterology, Vol 18, Iss 1, Pp 1-8 (2018)
Druh dokumentu: article
ISSN: 1471-230X
DOI: 10.1186/s12876-018-0901-0
Popis: Abstract Background Chronic autoimmune atrophic gastritis (CAAG) is an autoimmune disease characterized by hypo/achlorhydria. A role of CAAG in the pathogenesis of nutritional deficiencies has been reported, therefore we hypothesized a possible association between CAAG and 25-OH-Vitamin D [25(OH)D] deficiency. Aim of the present study is to evaluate the prevalence of 25(OH)D deficiency in CAAG patients. Methods: 87 CAAG patients (71 females; mean age 63.5 ± 12.8 years) followed at our Centre from January 2012 to July 2015 were consecutively evaluated. 25(OH)D, vitamin B12, parathormone, and calcium were measured in all the CAAG patients. The results were compared with a control group of 1232 healthy subjects. Results In the CAAG group the mean 25(OH)D levels were significantly lower than in the control group (18.8 vs. 27.0 ng/ml, p
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