| Autor: |
Rutger van der Schrier, Monique van Velzen, Margot Roozekrans, Elise Sarton, Erik Olofsen, Marieke Niesters, Chantal Smulders, Albert Dahan |
| Jazyk: |
angličtina |
| Rok vydání: |
2022 |
| Předmět: |
|
| Zdroj: |
Frontiers in Toxicology, Vol 4 (2022) |
| Druh dokumentu: |
article |
| ISSN: |
2673-3080 |
| DOI: |
10.3389/ftox.2022.1001709 |
| Popis: |
Background: Due the increasing need for storage of carbon dioxide (CO2) more individuals are prone to be exposed to high concentrations of CO2 accidentally released into atmosphere, with deleterious consequences.Methods: We tested the effect of increasing CO2 concentrations in humans (6–12%) and rats (10–50%) at varying inhalation times (10–60 min). In humans, a continuous positive airway pressure helmet was used to deliver the gas mixture to the participants. Unrestrained rats were exposed to CO2 in a transparent chamber. In both species regular arterial blood gas samples were obtained. After the studies, the lungs of the animals were examined for macroscopic and microscopic abnormalities.Results: In humans, CO2 concentrations of 9% inhaled for >10 min, and higher concentrations inhaled for |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
|
