Targeting the Bacterial Protective Armour; Challenges and Novel Strategies in the Treatment of Microbial Biofilm
| Autor: | Nor Fadhilah Kamaruzzaman, Li Peng Tan, Khairun Anisa Mat Yazid, Shamsaldeen Ibrahim Saeed, Ruhil Hayati Hamdan, Siew Shean Choong, Weng Kin Wong, Alexandru Chivu, Amanda Jane Gibson |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
biofilms
anti-biofilms nosocomial pathogens Staphylococcus aureus Pseudomonas aeruginosa Klebsiella pneumoniae Technology Electrical engineering. Electronics. Nuclear engineering TK1-9971 Engineering (General). Civil engineering (General) TA1-2040 Microscopy QH201-278.5 Descriptive and experimental mechanics QC120-168.85 |
| Zdroj: | Materials, Vol 11, Iss 9, p 1705 (2018) |
| Druh dokumentu: | article |
| ISSN: | 1996-1944 |
| DOI: | 10.3390/ma11091705 |
| Popis: | Infectious disease caused by pathogenic bacteria continues to be the primary challenge to humanity. Antimicrobial resistance and microbial biofilm formation in part, lead to treatment failures. The formation of biofilms by nosocomial pathogens such as Staphylococcus aureus (S. aureus), Pseudomonas aeruginosa (P. aeruginosa), and Klebsiella pneumoniae (K. pneumoniae) on medical devices and on the surfaces of infected sites bring additional hurdles to existing therapies. In this review, we discuss the challenges encountered by conventional treatment strategies in the clinic. We also provide updates on current on-going research related to the development of novel anti-biofilm technologies. We intend for this review to provide understanding to readers on the current problem in health-care settings and propose new ideas for new intervention strategies to reduce the burden related to microbial infections. |
| Databáze: | Directory of Open Access Journals |
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