Immune system reactivity in patients with chronic hepatitis С
| Autor: | D M Sobchak, O V Korochkina |
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| Jazyk: | ruština |
| Rok vydání: | 2008 |
| Předmět: | |
| Zdroj: | Терапевтический архив, Vol 80, Iss 2, Pp 61-66 (2008) |
| Druh dokumentu: | article |
| ISSN: | 0040-3660 2309-5342 |
| Popis: | Aim. To determine levels of IL-1beta, IL-2, IL-4, IL-6, TNF-alpha, IFN-alpha, IFN-gamma in patients with chronic hepatitis С (CHC). Material and methods. Peripheral blood cytokines were measured with enzyme immunoassay (Protein contur kits, St-Petersburg). Results. Higher content of IL-2, IFNa, IFNg was found in older patients with negative results of examination for HCV RNA, a/HCVcore IgM, a/HCV/ns3,5, genotype 3a, evidencing for higher reactivity of the immune system. High levels of IL-1beta, IL-6, TNFa were detected in young patients with narcotic drug consumption history, with high enxymatic activity, biliary inflammation, genotype lb, high index of histological activity. Conclusion. The above changes characterize the severity of morphological, necrotic-inflammatory changes in the liver. |
| Databáze: | Directory of Open Access Journals |
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