The role of vitamin D in metabolically unhealthy obesity in children
| Autor: | A. Abaturov, A. Nikulina |
|---|---|
| Jazyk: | English<br />Ukrainian |
| Rok vydání: | 2023 |
| Předmět: | |
| Zdroj: | Zdorovʹe Rebenka, Vol 18, Iss 2, Pp 94-100 (2023) |
| Druh dokumentu: | article |
| ISSN: | 2224-0551 2307-1168 |
| DOI: | 10.22141/2224-0551.18.2.2023.1568 |
| Popis: | Background. Vitamin D deficiency is associated with impaired glucose tolerance, insulin resistance, metabolic syndrome, and an increased risk of developing type 2 diabetes. Aim: to study the role of vitamin D levels associated with single nucleotide variants (SNV) of the vitamin D receptor (VDR) gene in the development of metabolically unhealthy obesity (MUO) in children. Materials and methods. Two hundred and ten obese children aged 6–18 years were examined. The main group (n = 125) was represented by children with MUO. The control group (n = 85) included children with metabolically healthy obesity (MHO). Whole genome sequencing (CeGat, Germany) was performed in 31 randomly selected children of the main and 21 children of the control group. The level of serum 25-hydroxyvitamin D (Synevo, Ukraine) was measured in all children. Verification of results: calculation of Spearman’s correlation coefficient (r) and p-value for each variable. Results. The mean serum level of 25-hydroxyvitamin D was significantly lower in children with MUO than in those with MHO: 14.57 ± 1.63 ng/mL versus 28.82 ± 1.93 ng/mL (t = 5.64, p = 0.00061). In patients with MUO, serum 25-hydroxyvitamin D levels are associated with the following predictors. Highly significant factors (0.7 ≤ |r| 0.5 (r = –0.41); AA genotype SNP VDR rs12721365 (r = –0.41) and AA genotype SNP VDR rs2228572 (r = –0.39); metabolic-associated fatty liver disease (r = –0.39); physiological postprandial glycemia (r = 0.38); level of interkeukin-1β (r = –0.36); triglyceridemia (r = –0.34); body mass index (r = –0.33); adiponectinemia (r = 0.32); arterial diastolic hypertension (r = –0.32). Low-significant factors (0 |
| Databáze: | Directory of Open Access Journals |
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