Dicer induced reactive oxygen species inhibit hepatocellular carcinoma through interacting with cytochrome c oxidase

Autor:	Lin Hou, Na Xing, Zhao Yue, Jianhua Wu, Fujun Wang, Zhanjun Guo
Jazyk:	angličtina
Rok vydání:	2022
Předmět:	Hepatocellular carcinoma dicer reactive oxygen species H2O2 Biotechnology TP248.13-248.65
Zdroj:	Biotechnology & Biotechnological Equipment, Vol 36, Iss 1, Pp 370-378 (2022)
Druh dokumentu:	article
ISSN:	13102818 1314-3530 1310-2818
DOI:	10.1080/13102818.2022.2082318
Popis:	AbstractDicer is an RNaseIII in microRNA processing that modulates multiple biological processes including tumorigenesis. We have shown that Dicer could inhibit the growth of hepatocellular carcinoma (HCC) previously [Zhang L, Wang C, Liu S, Zhao Y, et al. Oncol Lett 2016;11:3961-3966]. Here, we evaluated the relationships between Dicer and reactive oxygen species (ROS) as well as their modulation for HCC. We found Dicer expression was positively associated with ROS generation in HCC tissue at borderline statistical levels (p = .065); functional analysis showed Dicer could both induce the ROS generation (p
Databáze:	Directory of Open Access Journals
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