Emerging roles of lncRNAs in the post-transcriptional regulation in cancer

Autor: Rong-Zhang He, Di-Xian Luo, Yin-Yuan Mo
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Zdroj: Genes and Diseases, Vol 6, Iss 1, Pp 6-15 (2019)
Druh dokumentu: article
ISSN: 2352-3042
DOI: 10.1016/j.gendis.2019.01.003
Popis: Accumulating evidence indicates that long non-coding RNAs (lncRNAs) can play a pivotal role in regulation of diverse cellular processes. In particular, lncRNAs can serve as master gene regulators at transcriptional and posttranscriptional levels, leading to tumorigenesis. In this review, we discuss latest developments in lncRNA-meditated gene expression at the post-transcriptional level, including gene splicing, mRNA stability, protein stability and nuclear trafficking. Keywords: Alternative splicing, LncRNA, Posttranscriptional regulation, Protein stability, RNA binding proteins, RNA stability
Databáze: Directory of Open Access Journals