Investigation of the Anticancer Effects of Nanocomposite of the Modified Graphene Oxide with Isatin-3-Semicarbazone on the Retinoblastoma Cells (Y79) Invitro
| Autor: | Zahra Ramezani, Hasan Tahermansouri, Farhoush Kiani |
|---|---|
| Jazyk: | perština |
| Rok vydání: | 2021 |
| Předmět: | |
| Zdroj: | Majallah-i Dānishgāh-i ’Ulūm-i Pizishkī-i Īlām, Vol 29, Iss 5, Pp 75-88 (2021) |
| Druh dokumentu: | article |
| ISSN: | 1563-4728 2588-3135 |
| Popis: | Introduction: The most common ocular tumor is retinoblastoma, which can be treated by different methods. The use of carbon nanostructures has attracted much attention due to their unique properties, such as crossing cell membranes, for cancer diagnosis and other medical applications. This study aimed to investigate and assess the toxicity of the modified graphene oxide (GO) with isatin-3-semicarbazone (ISA) in order to treat retinoblastoma. Material & Methods: This study utilized ISA to modify the GO. Subsequently, the modified GO-ISA was characterized by different techniques, such as Fourier transform infrared spectrometry, Scanning Electron Microscope, and Thermal Gravimetric Analysis. The cell toxicity of samples was assessed by MTT assay for two types of cells of retinoblastoma (Y79) and adipose-derived stem cells (ADSC) after 24 h at different concentrations. Data were analyzed in SPSS software using one-way analysis of variance (ANOVA). A p-value less than 0.05 was considered statistically significant. Findings: The results showed that in the concentration range of 10-50 µL, GO-ISA decreased significantly (P |
| Databáze: | Directory of Open Access Journals |
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