Nidogen‐1 Mitigates Ischemia and Promotes Tissue Survival and Regeneration
| Autor: | Aline Zbinden, Shannon L. Layland, Max Urbanczyk, Daniel A. Carvajal Berrio, Julia Marzi, Monika Zauner, Anne Hammerschmidt, Eva M. Brauchle, Katrin Sudrow, Simon Fink, Markus Templin, Simone Liebscher, Gerd Klein, Arjun Deb, Garry P. Duffy, Gay M. Crooks, Johannes A. Eble, Hanna K. A. Mikkola, Ali Nsair, Martina Seifert, Katja Schenke‐Layland |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: | |
| Zdroj: | Advanced Science, Vol 8, Iss 4, Pp n/a-n/a (2021) |
| Druh dokumentu: | article |
| ISSN: | 2198-3844 20200250 |
| DOI: | 10.1002/advs.202002500 |
| Popis: | Abstract Ischemia impacts multiple organ systems and is the major cause of morbidity and mortality in the developed world. Ischemia disrupts tissue homeostasis, driving cell death, and damages tissue structure integrity. Strategies to heal organs, like the infarcted heart, or to replace cells, as done in pancreatic islet β‐cell transplantations, are often hindered by ischemic conditions. Here, it is discovered that the basement membrane glycoprotein nidogen‐1 attenuates the apoptotic effect of hypoxia in cardiomyocytes and pancreatic β‐cells via the αvβ3 integrin and beneficially modulates immune responses in vitro. It is shown that nidogen‐1 significantly increases heart function and angiogenesis, while reducing fibrosis, in a mouse postmyocardial infarction model. These results demonstrate the protective and regenerative potential of nidogen‐1 in ischemic conditions. |
| Databáze: | Directory of Open Access Journals |
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