Aqueous extract of Carpolobia lutea root ameliorates paroxetine-induced anti-androgenic activity in male rats

Autor: Musa Toyin Yakubu, Rukayat Oluwatoyin Jimoh
Jazyk: angličtina
Rok vydání: 2015
Předmět:
Zdroj: Middle East Fertility Society Journal, Vol 20, Iss 3, Pp 192-197 (2015)
Druh dokumentu: article
ISSN: 1110-5690
DOI: 10.1016/j.mefs.2014.10.001
Popis: Study objective: This study aimed to investigate the effects of aqueous extract of Carpolobia lutea root on the androgenic indices of paroxetine-treated male rats. Materials and methods: Sexually active, male rats (133.10 ± 4.21 g) were completely randomized into five groups (A–E) of 5 animals each. Rats in group A received 0.5 ml of distilled water once daily for 7 days while those in groups B, C, D and E which were induced with anti-androgenicity (oral administration of 10 mg/kg of paroxetine suspension, once daily for 21 days) received 0.5 ml of distilled water and 0.5 ml corresponding to 47, 94 and 141 mg/kg body weight of the extract respectively. Outcome: Administration of paroxetine significantly (p
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