OPTIMIZATION OF SOLID-PHASE SYNTHESIS OF POLYAMIDE NUCLEIC ACID MIMETICS WITH APPLICATION OF MALDI-TOF MASS-SPECTROMETRY

Autor:	M. V. Shirayeva, Yu. G. Kirillova, E. D. Nikol’Skaya, D. I. Prokhorov, I. P. Smirnov, G. E. Pozmogova
Jazyk:	ruština
Rok vydání:	2013
Předmět:	полиамидные миметики нуклеиновых кислот пептидно-нуклеиновые кислоты (пнк) твердофазный синтез maldi-tof-масс-спектрометрия polyamide nucleic acid mimetics (panam) peptide nucleic acids (pna) solid phase synthesis maldi-tof mass-spectrometry Chemistry QD1-999
Zdroj:	Тонкие химические технологии, Vol 8, Iss 1, Pp 87-95 (2013)
Druh dokumentu:	article
ISSN:	2410-6593 2686-7575
Popis:	The solid-phase synthesis of a tetrameric model sequence of polyamide nucleic acid mimetics (PANAM) incorporating terminal chiral and charged unit was performed. As a result during the synthesis and cleavage from the resin the tendency of PANAM with the N-terminal negatively charged monomer to cyclization with simultaneous N-acyl transfer of carboxyethyl base residue was found. Application of MALDI-TOF mass - spectrometry allowed us to find suitable conditions for obtaining PANAM oligomers without the significant amount of by-products.
Databáze:	Directory of Open Access Journals
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