Autor: |
Sarah Alshammery, Shrujna Patel, Hannah F. Jones, Velda X. Han, Brian S. Gloss, Wendy A. Gold, Russell C. Dale |
Jazyk: |
angličtina |
Rok vydání: |
2022 |
Předmět: |
|
Zdroj: |
Frontiers in Neuroscience, Vol 16 (2022) |
Druh dokumentu: |
article |
ISSN: |
1662-453X |
DOI: |
10.3389/fnins.2022.999346 |
Popis: |
Neurodevelopmental disorders (NDDs), including autism-spectrum disorders (ASD) and Tourette syndrome (TS) are common brain conditions which often co-exist, and have no approved treatments targeting disease mechanisms. Accumulating literature implicates the immune system in NDDs, and transcriptomics of post-mortem brain tissue has revealed an inflammatory signal. We interrogated two RNA-sequencing datasets of ASD and TS and identified differentially expressed genes, to explore commonly enriched pathways through GO, KEGG, and Reactome. The DEGs [False Discovery Rate (FDR) |
Databáze: |
Directory of Open Access Journals |
Externí odkaz: |
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