Endothelial PDGF-CC regulates angiogenesis-dependent thermogenesis in beige fat
| Autor: | Takahiro Seki, Kayoko Hosaka, Sharon Lim, Carina Fischer, Jennifer Honek, Yunlong Yang, Patrik Andersson, Masaki Nakamura, Erik Näslund, Seppo Ylä-Herttuala, Meili Sun, Hideki Iwamoto, Xuri Li, Yizhi Liu, Nilesh J. Samani, Yihai Cao |
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| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: | |
| Zdroj: | Nature Communications, Vol 7, Iss 1, Pp 1-16 (2016) |
| Druh dokumentu: | article |
| ISSN: | 2041-1723 14440407 |
| DOI: | 10.1038/ncomms12152 |
| Popis: | Cold-induced activation of thermogenesis in white adipose tissue (WAT), or ‘beiging’, is associated with WAT angiogenesis. Here the authors show that PDGF-CC is secreted from endothelial cells in the context of WAT angiogenesis and its paracrine action on adipocytes contributes to cold-induced beiging. |
| Databáze: | Directory of Open Access Journals |
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