Spontaneous retinal pigment epithelial tear in type 2 choroidal neovascularization: repair mechanisms following anti-VEGF therapy

Autor: Giuseppe Casalino, Vasuki Sivagnanavel, Samir Dowlut, Pearse A. Keane, Usha Chakravarthy
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Zdroj: International Journal of Retina and Vitreous, Vol 5, Iss 1, Pp 1-4 (2019)
Druh dokumentu: article
ISSN: 2056-9920
DOI: 10.1186/s40942-019-0155-1
Popis: Abstract Background To report the clinical course and the multimodal retinal imaging of a spontaneous retinal pigment epithelial (RPE) tear in a type 2 choroidal neovascularization (CNV) secondary to age-related macular degeneration treated with anti-vascular endothelial growth factor (VEGF) treatment. Case presentation A 74 year-old man presented with visual acuity deterioration in the right eye. Multimodal retinal imaging showed a predominantly classic (type 2) CNV complicated by a spontaneous RPE tear. The patient received six intravitreal injections of anti-VEGF which resulted in improvement of the vision and stabilization of the neovascular lesion on optical coherence tomography (OCT). Longitudinal changes of the RPE-photoreceptors interface, including RPE splitting, are reported on OCT. Conclusion RPE tears may spontaneously occur in type 2 CNV. Anti-VEGF treatment should be aimed at promoting RPE repair and limiting the extent of the scarring. The mechanisms of RPE repair during treatment may be documented with OCT.
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