Case series of seven women with uterine fibroids associated with venous thromboembolism and chronic thromboembolic disease

Autor: Anne-Sophie Lacharite-Roberge, Farhan Raza, Riyaz Bashir, Chandra A. Dass, G. William Moser, William R. Auger, Yoshiya Toyoda, Paul R. Forfia, Anjali Vaidya
Jazyk: angličtina
Rok vydání: 2018
Předmět:
Zdroj: Pulmonary Circulation, Vol 9 (2018)
Druh dokumentu: article
ISSN: 2045-8940
20458940
DOI: 10.1177/2045894018803873
Popis: Uterine fibroids have been described as an associate to acute venous thromboembolism (VTE), with case reports showing an association between large uterine fibroids, acute deep venous thrombosis (DVT), and acute pulmonary embolism (PE). However, there is little known about the association or causation between uterine fibroids, chronic thromboembolic disease (CTED), and chronic thromboembolic pulmonary hypertension (CTEPH). We report on six women with uterine fibroids and CTEPH, as well as one woman with CTED, all of whom presented with exertional dyspnea, lower extremity swelling, and in the cases of CTEPH, clinical, echocardiographic, and hemodynamic evidence of pulmonary hypertension and right heart failure. Compression of the pelvic veins by fibroids was directly observed with invasive venography or contrast-enhanced computed tomography in five cases. All seven women underwent pulmonary thromboendarterectomy (PTE) followed by marked improvement in functional, clinical, and hemodynamic status.
Databáze: Directory of Open Access Journals
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