Prenatal and childhood arsenic exposure through drinking water and food and cognitive abilities at 10 years of age: A prospective cohort study

Autor: Marie Vahter, Helena Skröder, Syed Moshfiqur Rahman, Michael Levi, Jena Derakhshani Hamadani, Maria Kippler
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Zdroj: Environment International, Vol 139, Iss , Pp - (2020)
Druh dokumentu: article
ISSN: 0160-4120
DOI: 10.1016/j.envint.2020.105723
Popis: Background: Our studies of children in a rural Bangladeshi area, with varying concentrations of arsenic in well-water, indicated modest impact on child verbal cognitive function at 5 years of age. Objectives: Follow-up of arsenic exposure and children’s cognitive abilities at school-age. Methods: In a nested sub-cohort of the MINIMat supplementation trial, we assessed cognitive abilities at 10 years of age (n = 1523), using Wechsler Intelligence Scale for Children (WISC-IV). Arsenic in maternal urine and erythrocytes in early pregnancy, in child urine at 5 and 10 years, and in hair at 10 years, was measured using Inductively Coupled Plasma Mass Spectrometry. Results: Median urinary arsenic at 10 years was 58 µg/L (range 7.3–940 µg/L). Multivariable-adjusted regression analysis showed that, compared to the first urinary arsenic quintile at 10 years (
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