Genetic association analysis identifies a role for ANO5 in prostate cancer progression

Autor:	Chia‐Cheng Yu, Lih‐Chyang Chen, Chao‐Yuan Huang, Victor C. Lin, Te‐Ling Lu, Cheng‐Hsueh Lee, Shu‐Pin Huang, Bo‐Ying Bao
Jazyk:	angličtina
Rok vydání:	2020
Předmět:	anoctamin biomarker prognosis progression prostate cancer Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Zdroj:	Cancer Medicine, Vol 9, Iss 7, Pp 2372-2378 (2020)
Druh dokumentu:	article
ISSN:	2045-7634
DOI:	10.1002/cam4.2909
Popis:	Abstract Anoctamins were originally identified as a family of calcium‐activated chloride channels, but recently their roles in the development of different types of malignancies were suggested. Here, we evaluated the associations between 211 common single‐nucleotide polymorphisms in 10 anoctamin genes with biochemical recurrence (BCR) after radical prostatectomy (RP) for localized prostate cancer. Four SNPs (ANO4 rs585335, ANO5 rs4622263, ANO7 rs62187431, and ANO10 rs118005571) remained significantly associated with BCR after multiple test correction (P
Databáze:	Directory of Open Access Journals
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