A Challenging Case of Severe Ulcerative Colitis following the Initiation of Secukinumab for Ankylosing Spondylitis

Autor: Dean Ehrlich, Nimah Jamaluddin, Joseph Pisegna, David Padua
Jazyk: angličtina
Rok vydání: 2018
Předmět:
Zdroj: Case Reports in Gastrointestinal Medicine, Vol 2018 (2018)
Druh dokumentu: article
ISSN: 2090-6528
2090-6536
DOI: 10.1155/2018/9679287
Popis: Secukinumab is an interleukin-17 inhibitor used for the treatment of ankylosing spondylitis (AS), psoriasis, and psoriatic arthritis. The risk of exacerbating underlying inflammatory bowel disease (IBD) in patients being treated with secukinumab for other conditions is controversial. We document a patient with AS and previously undiagnosed IBD, found to be in a severe ulcerative colitis flare shortly after receiving the loading dose of secukinumab. There are no guidelines regarding biologic salvage therapy for IBD in the setting of active treatment with another biologic agent. After waiting one half-life of secukinumab, our patient had an excellent response to initiation of infliximab.
Databáze: Directory of Open Access Journals
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