Connective tissue fibroblasts from highly regenerative mammals are refractory to ROS-induced cellular senescence

Autor: Sandeep Saxena, Hemendra Vekaria, Patrick G. Sullivan, Ashley W. Seifert
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Zdroj: Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
Druh dokumentu: article
ISSN: 2041-1723
DOI: 10.1038/s41467-019-12398-w
Popis: In regenerative animals, how cells respond to injury signals inducing senescence is unclear. Here, the authors show that cells from highly regenerative mammals are resistant to ROS-induced cellular senescence, but non-regenerating species exhibit mitochondrial dysfunction/senescence in response to hydrogen peroxide exposure.
Databáze: Directory of Open Access Journals