| Autor: |
Koji Obara, Tsuyoshi Imota, Shigeo Mamiya, Itaru Toyoshima |
| Jazyk: |
angličtina |
| Rok vydání: |
2020 |
| Předmět: |
|
| Zdroj: |
Case Reports in Neurology, Vol 12, Iss 3, Pp 270-275 (2020) |
| Druh dokumentu: |
article |
| ISSN: |
1662-680X |
| DOI: |
10.1159/000508357 |
| Popis: |
Epileptic seizures are common in the elderly Down syndrome population. We encountered a patient with Down syndrome in whom karyotyping showed the rare isodicentric chromosome 21 and who suffered from myoclonic seizures. A 52-year-old woman with Down syndrome experienced sudden onset of drowsiness and frequent myoclonic jerks in the upper body. Video-EEG recordings demonstrated generalized polyspike-wave discharges consistent with myoclonic jerks, which were exacerbated by photo-stimulation. Her myoclonus completely resolved with perampanel administration. Perampanel was effective for myoclonic seizures in our patient. We suggest that perampanel is an option as first-line therapy for epilepsy and myoclonus in elderly Down syndrome patients. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
|
