| Autor: |
P. Vijaya Babu, Mohd Ashraf Ashfaq, K. Shiva Kumar, K. Mukkanti, Manojit Pal |
| Jazyk: |
angličtina |
| Rok vydání: |
2019 |
| Předmět: |
|
| Zdroj: |
Arabian Journal of Chemistry, Vol 12, Iss 8, Pp 2749-2759 (2019) |
| Druh dokumentu: |
article |
| ISSN: |
1878-5352 |
| DOI: |
10.1016/j.arabjc.2015.05.018 |
| Popis: |
Prompted by the literature report on anticancer properties of mefenamic acid, a series of mefenamic acid based indole derivatives were designed via a rational approach. Synthesis of this class of compounds was carried out via a 3-step method starting from the mefenamic acid and using the Pd/C–Cu mediated coupling-cyclization strategy as a key step. A focused library of related molecules was synthesized and evaluated for their anti-proliferative properties against normal (HEK293T) and oral (CAL 27) as well as breast (MCF-7) cancer cell lines when several compounds showed selective growth inhibition of oral cancer cells of which the compound 5g [i.e. N-(2-(((5-fluoro-1-(methylsulfonyl)-1H-indol-2-yl)methoxy)methyl)phenyl)-2,3-dimethylaniline] was found to be promising. Keywords: Mefenamic acid, Indole, Pd/C, Cancer |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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