Characterization of 1H NMR and 13C NMR Spectrometry and Antibacterial Activities of 4-tert-Butylbenzoyl Amoxicillin

Autor:	Hadi Barru Hakam Fajar Siddiq, Dewi Rashati, Siti Nur Azizah
Jazyk:	angličtina
Rok vydání:	2022
Předmět:	4-tert-butylbenzoyl amoxicillin bacillus subtilis escherichia coli spectrometry staphylococcus aureus Pharmacy and materia medica RS1-441
Zdroj:	Jurnal Farmasi Sains dan Komunitas, Vol 19, Iss 1, Pp 29-33 (2022)
Druh dokumentu:	article
ISSN:	1693-5683 2527-7146
DOI:	10.24071/jpsc.002183
Popis:	The synthesis of 4-tert-butylbenzoyl amoxicillin has been done by reacting amoxicillin with 4-tert-butylbenzoyl chloride. The product was characterized using proton and carbon-13 spectrometry. Antibacterial activity of 4-tert-butylbenzoyl amoxicillin against Escherichia coli, Bacillus subtilis, and Staphylococcus aureus was tested using paper disk diffusion method. Results showed that 4-tert-butylbenzoyl amoxicillin had a specific spectrum activity. Antibacterial test of 4-tert-butylbenzoyl amoxicillin showed clear zones around the disc paper for Escherichia coli, Bacillus subtilis, and Staphylococcus aureus. The study results indicated 4-tert-butylbenzoyl amoxicillin has antimicrobial properties but is categorized as a less-effective antibiotic agent based on the response to bacterial growth inhibition.
Databáze:	Directory of Open Access Journals
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