HIV-1 Tropism Testing and Clinical Management of CCR5 Antagonists: Quebec Review and Recommendations

Autor: Cécile Tremblay, Isabelle Hardy, Richard Lalonde, Benoit Trottier, Irina Tsarevsky, Louis-Philippe Vézina, Michel Roger, Mark Wainberg, Jean-Guy Baril
Jazyk: angličtina
Rok vydání: 2013
Předmět:
Zdroj: Canadian Journal of Infectious Diseases and Medical Microbiology, Vol 24, Iss 4, Pp 202-208 (2013)
Druh dokumentu: article
ISSN: 1712-9532
54311799
DOI: 10.1155/2013/982759
Popis: HIV-1 tropism assays play a crucial role in determining the response to CCR5 receptor antagonists. Initially, phenotypic tests were used, but limited access to these tests prompted the development of alternative strategies. Recently, genotyping tropism has been validated using a Canadian technology in clinical trials investigating the use of maraviroc in both experienced and treatment-naive patients. The present guidelines review the evidence supporting the use of genotypic assays and provide recommendations regarding tropism testing in daily clinical management.
Databáze: Directory of Open Access Journals
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