Aqueous garlic extract improves renal clearance via vasodilatory/antioxidant mechanisms and mitigated proteinuria via stabilization of glomerular filtration barrier

Autor: Christian Eseigbe Imafidon, Rufus Ojo Akomolafe, Omotayo Alaba Eluwole, Isiaka Ayofe Adekunle, Ruby Adebusola Agbaje
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Zdroj: Clinical Phytoscience, Vol 5, Iss 1, Pp 1-13 (2019)
Druh dokumentu: article
ISSN: 2199-1197
DOI: 10.1186/s40816-019-0118-y
Popis: Abstract Background Lead (Pb) remains an apparently indispensable material in several industrial processes. It is a potent environmental toxin with associated deleterious biological effects. The study investigated the effects of aqueous garlic extract (AGE) on renal clearance and proteinuria in Wistar rats with Pb-induced kidney injury. Methods Thirty male Wistar rats were divided into six groups of five rats each such that exposure to Pb (35 mg/kg i.p) for 10 consecutive days was either followed by 30 days recovery period (without treatment) or 30 days post-treatment with oral graded doses of AGE at 100, 200 and 400 mg/kg while comparisons where made against a control (2 ml/kg NORMAL SALINE) at p
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