Highly-expressed lncRNA FOXD2-AS1 in adipose mesenchymal stem cell derived exosomes affects HaCaT cells via regulating miR-185-5p/ROCK2 axis

Autor:	Huanchao Chang, Junliang Chen, Kun Ding, Tianling Cheng, Shengjian Tang
Jazyk:	angličtina
Rok vydání:	2023
Předmět:	Exosomes FOXD2-AS1 wound healing miR-185-5p ROCK2 Diseases of the endocrine glands. Clinical endocrinology RC648-665 Cytology QH573-671 Physiology QP1-981
Zdroj:	Adipocyte, Vol 12, Iss 1 (2023)
Druh dokumentu:	article
ISSN:	21623945 2162-397X 2162-3945
DOI:	10.1080/21623945.2023.2173513
Popis:	ABSTRACTThe healing of skin wounds is a highly coordinated multi-step process that occurs after trauma including surgical incisions, thermal burns, and chronic ulcers. In this study, the authors investigated lncRNA FOXD2-AS1 function in adipose mesenchymal exosomes from ADMSCs that were successfully extracted. Highly expressed lncRNA FOXD2-AS1 in ADMSCs-exosomes accelerated HaCaT cell migration and proliferation. LncRNA FOXD2-AS1 negatively targeted miR-185-5p, and miR-185-5p negatively targeted ROCK2. Highly expressed lncRNA FOXD2-AS1 in ADMSCs-exosomes promoted HaCaT cell migration and proliferation via down-regulating miR-185-5p and further up-regulating ROCK2. In conclusion, LncRNA FOXD2-AS1 overexpression in ADMSCs derived exosomes might accelerate HaCaT cell migration and proliferation via modulating the miR-185-5p/ROCK2 axis.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/2b2b31181a3545a6be60a2430693cf71 Zobrazit plný text záznamu View record in DOAJ