| Autor: |
Alan Getgood, Frances Henson, Carrie Skelton, Roger Brooks, Hans Guehring, Lisa A Fortier, Neil Rushton |
| Jazyk: |
angličtina |
| Rok vydání: |
2014 |
| Předmět: |
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| Zdroj: |
Journal of Experimental Orthopaedics, Vol 1, Iss 1, Pp n/a-n/a (2014) |
| Druh dokumentu: |
article |
| ISSN: |
2197-1153 |
| DOI: |
10.1186/s40634-014-0013-x |
| Popis: |
Abstract Background The aim of this study was to investigate the effect of combining rhFGF18 or BMP‐7 with a biphasic collagen/GAG osteochondral scaffold (Chondromimetic) on the repair of osteochondral defects in sheep. Methods Osteochondral defects (5.8×6mm) were created in the medial femoral condyle (MFC) and the lateral trochlea sulcus (LTS) of the stifle joint of 24 female sheep. Sheep were randomly assigned to four groups (n = 6); 1) empty defect, 2) scaffold only, 3) scaffold + rhFGF‐18 (30 μg) and 4) scaffold + BMP‐7 (100 μg). At 6 months the defects underwent non‐destructive mechanical testing, gross assessment of repair tissue (ICRS score) and histological analysis (Modified O’Driscoll score). Results ICRS repair score: Defects treated with scaffold + rhFGF18 (mean 9.83, 95% CI 8.43‐11.23) and scaffold + BMP‐7 (10, 9.06‐10.94) in the MFC had significantly improved ICRS scores compared to empty defects (4.2, 0–8.80) (p = 0.002). Mechanical properties: BMP‐7 treated defects (mean 64.35, 95% CI 56.88‐71.82) were significantly less stiff than both the rhFGF18 (mean 84.1, 95% CI 76.8‐91.4) and empty defects in the LTS, compared to both contralateral limb (p = 0.003), and the perilesional articular cartilage (p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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