Association between COVID-19 infection and herpes zoster: A case series
| Autor: | Murali Narasimhan, Ramachandran Ramakrishnan, Priya Cinna T. Durai, Boggarapu Sneha |
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| Jazyk: | angličtina |
| Rok vydání: | 2023 |
| Předmět: | |
| Zdroj: | Journal of Family Medicine and Primary Care, Vol 12, Iss 10, Pp 2516-2519 (2023) |
| Druh dokumentu: | article |
| ISSN: | 2249-4863 2278-7135 |
| DOI: | 10.4103/jfmpc.jfmpc_2112_22 |
| Popis: | Herpes zoster (HZ) is a manifestation of the reactivation of latent varicella zoster virus (VZV) infection in the dorsal root ganglion. The occurrence of HZ has been reported in association with COVID-19. Herein, we describe 10 cases who developed classic HZ within 2–3 weeks of acquiring COVID-19 infection. The triggers in these patients could be severe stress (related to quarantine issues, fear of hospitalisation and death) immune dysregulation and systemic steroid therapy in treating COVID-19. The clinical patterns and therapeutic responses observed were similar to HZ in immunocompetent persons. Increased expression of NKG2A on NK and CD8+ T cells has been proposed as a pathophysiologic mechanism in triggering HZ at the molecular level in COVID-19 patients. Primary physicians should be aware of this association to counsel and treat such patients appropriately, as initiating early treatment could minimise the risk of complications like postherpetic neuralgia. |
| Databáze: | Directory of Open Access Journals |
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