Acute Myleoid Leukaemia t(8;21)- A Close Differential Diagnosis to Myelodysplastic Syndrome with Excess Blasts-2: A Case Report
| Autor: | Bhusari Harveen, Masamati Smita |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | Journal of Clinical and Diagnostic Research, Vol 16, Iss 7, Pp ED01-ED03 (2022) |
| Druh dokumentu: | article |
| ISSN: | 2249-782X 0973-709X |
| DOI: | 10.7860/JCDR/2022/54982.16562 |
| Popis: | Acute Myeloid Leukaemia (AML) with t(8;21) (q22;22) is a distinct, rare type of AML, generally occurs in young patients which has a favorable prognosis. It is found in approximately 5% cases of all AML. This translocation (8;21) usually correlates with specific morphological features which include large blasts with auer rods and large Pseudo-Chediak-Higashi granules in neutrophils. These features are also seen in myelodysplasia related changes, hence should be differentiated as the latter have worse prognosis. Detection of chromosomal abnormalities by cytogenetics is very important for risk stratification and prognosis. Hence, authors reports a very unusual case of AML t(8;21) in a 32-year-old female patient presented with features of Myelodysplastic Syndrome (MDS) with Excess Blasts-2. |
| Databáze: | Directory of Open Access Journals |
| Externí odkaz: |
|