Highly variable biological effects of statins on cancer, non-cancer, and stem cells in vitro

Autor:	Helena Gbelcová, Silvie Rimpelová, Adriana Jariabková, Patrik Macášek, Petra Priščáková, Tomáš Ruml, Jana Šáchová, Jan Kubovčiak, Michal Kolář, Libor Vítek
Jazyk:	angličtina
Rok vydání:	2024
Předmět:	Pancreatic cancer cells Stem cells Microarray analysis Cell spheroids 3-Hydroxy-3-methylglutaryl coenzyme A inhibitors Statins Medicine Science
Zdroj:	Scientific Reports, Vol 14, Iss 1, Pp 1-11 (2024)
Druh dokumentu:	article
ISSN:	2045-2322
DOI:	10.1038/s41598-024-62615-w
Popis:	Abstract Statins, the drugs used for the treatment of hypercholesterolemia, have come into the spotlight not only as chemoadjuvants, but also as potential stem cell modulators in the context of regenerative therapy. In our study, we compared the in vitro effects of all clinically used statins on the viability of human pancreatic cancer (MiaPaCa-2) cells, non-cancerous human embryonic kidney (HEK 293) cells and adipose-derived mesenchymal stem cells (ADMSC). Additionally, the effect of statins on viability of MiaPaCa-2 and ADMSC cells spheroids was tested. Furthermore, we performed a microarray analysis on ADMSCs treated with individual statins (12 μM) and compared the importance of the effects of statins on gene expression between stem cells and pancreatic cancer cells. Concentrations of statins that significantly affected cancer cells viability (
Databáze:	Directory of Open Access Journals
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