β-Glucan from mushrooms and dates as a wall material for targeted delivery of model bioactive compound: Nutraceutical profiling and bioavailability

Autor: Asima Shah, Zanoor ul Ashraf, Asir Gani, F.A. Masoodi, Adil Gani
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Ultrasonics Sonochemistry, Vol 82, Iss , Pp 105884- (2022)
Druh dokumentu: article
ISSN: 1350-4177
DOI: 10.1016/j.ultsonch.2021.105884
Popis: Rutin was nano-encapsulated in date [En-Ru(D)] and mushroom [En-Ru(M)] β-glucan matrix to protect it from the harsh gastrointestinal environment and to enhance its bioavailability and biological activity upon digestion. The encapsulation was carried using green technology i.e., ultra-sonication. The En-Ru(D) and En-Ru (M) showed the hydrodynamic diameter of 314.04 and 482.21 nm with polydispersity index of 0.21 and 0.33. The in vitro release behaviour followed the Higuchi model. The antimicrobial activity of En-Ru(D) and En-Ru(M) were evaluated against gram negative E. coli (ATCC 25922) and gram positive (Staphylococcus aureus) bacteria. Furthermore, En-Ru(D) and En-Ru(M) exhibited increased bioavailability of rutin in intestinal fluid with retention of anti-obesity and antioxidant activities after digestion (p
Databáze: Directory of Open Access Journals