| Autor: |
Alexandre Maximiliano Trevisan, Bruno Cogliati, Adriana Ribeiro Homem, Thiago Pinheiro Arrais Aloiav, Nelson de Aquino Neto, Jairo Marques Moreira, Leonardo da Cruz Reno, Alexandre Moulin Naumann, Flavio Henrique Ferreira Galvão, Wellington Andraus, Luiz Augusto Carneiro D'Albuquerque |
| Jazyk: |
angličtina |
| Rok vydání: |
2019 |
| Předmět: |
|
| Zdroj: |
Acta Cirúrgica Brasileira, Vol 34, Iss 10 (2019) |
| Druh dokumentu: |
article |
| ISSN: |
0102-8650 |
| DOI: |
10.1590/s0102-865020190100000003 |
| Popis: |
Abstract Purpose: To evaluate that Connexin (Cx43) plays a role in lesions after hepatic ischemia/reperfusion (IR) injury. Methods: We use Cx43 deficient model (heterozygotes mice) and compared to a wild group. The groups underwent 1 hour ischemia and 24 hours reperfusion. The heterozygote genotype was confirmed by PCR. We analyzed the hepatic enzymes (AST, ALT, GGT) and histology. Results: The mice with Cx43 deficiency showed an ALT mean value of 4166 vs. 307 in the control group (p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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