Maternal N-carbamylglutamate and L-arginine supplementations improve foetal jejunal oxidation resistance, integrity and immune function in malnutrition sheep during pregnancy

Autor:	Hao Zhang, Bei Zhang, Huisi Wu, Xia Zha, Mabrouk Elsabagh, Jingwen Zhao, Hongrong Wang, Mengzhi Wang, Guihua Shu
Jazyk:	angličtina
Rok vydání:	2024
Předmět:	intrauterine growth restriction intestinal integrity l-arginine n-carbamylglutamate oxidation resistance Animal culture SF1-1100
Zdroj:	Italian Journal of Animal Science, Vol 23, Iss 1, Pp 989-1001 (2024)
Druh dokumentu:	article
ISSN:	1594-4077 1828-051X 1828051X
DOI:	10.1080/1828051X.2024.2374870
Popis:	The present work focused on examining the function of rumen-protected L-arginine (RP-Arg) or N-carbamylglutamate (NCG) in jejunal oxidative resistance, integrity and immune function in the ovine foetal model of intrauterine growth restriction (IUGR). Thirty-two twin-bearing Hu ewes at d 35 of gestation were randomised as 4 treatment groups (n = 8 each): Control (CON), received 100% of the recommended National Research Council (NRC) for pregnancy; Restricted (RES), received 50% of the recommended NRC for pregnancy; RES + ARG, RES ewes added with 20 g/d of RP-Arg; or RES + NCG treatment, RES ewes added with 5 g/d of NCG. Foetal jejunal samples were collected on d 110 of pregnancy and were assayed for biomarkers of oxidative damage, integrity and immune function. The villus height was elevated (p
Databáze:	Directory of Open Access Journals
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