| Autor: |
Jun Yang, Jifang Zheng, Jianjian Qiu, Mengyan Zhang, Lingyun Liu, Zhiping Wang, Qunhao Zheng, Yanyan Liu, Mingqiu Chen, Jiancheng Li |
| Jazyk: |
angličtina |
| Rok vydání: |
2023 |
| Předmět: |
|
| Zdroj: |
Journal of Immunology Research, Vol 2023 (2023) |
| Druh dokumentu: |
article |
| ISSN: |
2314-7156 |
| DOI: |
10.1155/2023/4275998 |
| Popis: |
Background. Systemic inflammation may be involved in the entire cancer process as a promoter and is associated with antitumor immunity. The systemic immune-inflammation index (SII) has been shown to be a promising prognostic factor. However, the relationship between SII and tumor-infiltrating lymphocytes (TIL) have not been established in esophageal cancer (EC) patients receiving concurrent chemoradiotherapy (CCRT). Methods. Retrospective analysis of 160 patients with EC was performed, peripheral blood cell counts were collected, and TIL concentration was assessed in H&E-stained sections. Correlations of SII and clinical outcomes with TIL were analyzed. Cox proportional hazard model and Kaplan–Meier method were used to perform survival outcomes. Results. Compared with high SII, low SII had longer overall survival (OS) (P=0.036, hazard ratio (HR) = 0.59) and progression-free survival (PFS) (P=0.041, HR = 0.60). Low TIL showed worse OS (P |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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