| Autor: |
Walter Torsten, Wyrwa Ralf, Altmann Cindy, Schnabelrauch Matthias |
| Jazyk: |
angličtina |
| Rok vydání: |
2021 |
| Předmět: |
|
| Zdroj: |
Current Directions in Biomedical Engineering, Vol 7, Iss 2, Pp 688-691 (2021) |
| Druh dokumentu: |
article |
| ISSN: |
2364-5504 |
| DOI: |
10.1515/cdbme-2021-2175 |
| Popis: |
A micro-sized core-shell drug release device has been prepared by coaxial electrospinning based on a polylactide shell and the inner core phase made of high molecular weight hyaluronan or a cross-linked hyaluronan network. Timolol, which was inserted into the core phase, is widely used as drug for glaucoma treatment to depress the intraocular eye pressure and should be released over a longer time period from this fiber networks. Release studies of drug loaded fiber devices showed an only moderate burst release of timolol in the first days followed by a continuous longlasting drug release period over several weeks. With these findings, coaxial electrospinning represents a promising approach for the development of drug release systems with long-lasting, relatively constant drug delivery. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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