| Autor: |
Ingrid Muller, Miriam Santer, Beth Stuart, Paul Little, Matthew J Ridd, Karen Thomas, Nick Francis, Kim S Thomas, Gareth Griffiths, Natalia V Permyakova, Jacqui Nuttall, Irene Soulsby, Alison M Layton, Tracey H Sach, Sarah Pyne, Susanne Renz, Zina Eminton, Megan Lawrence |
| Jazyk: |
angličtina |
| Rok vydání: |
2023 |
| Předmět: |
|
| Zdroj: |
BMJ Open, Vol 13, Iss 12 (2023) |
| Druh dokumentu: |
article |
| ISSN: |
2044-6055 |
| DOI: |
10.1136/bmjopen-2023-073245 |
| Popis: |
Objective This study aims to estimate the cost-effectiveness of oral spironolactone plus routine topical treatment compared with routine topical treatment alone for persistent acne in adult women from a British NHS perspective over 24 weeks.Design Economic evaluation undertaken alongside a pragmatic, parallel, double-blind, randomised trial.Setting Primary and secondary healthcare, community and social media advertising.Participants Women ≥18 years with persistent facial acne judged to warrant oral antibiotic treatment.Interventions Participants were randomised 1:1 to 50 mg/day spironolactone (increasing to 100 mg/day after 6 weeks) or matched placebo until week 24. Participants in both groups could continue topical treatment.Main outcome measures Cost-utility analysis assessed incremental cost per quality-adjusted life year (QALY) using the EQ-5D-5L. Cost-effectiveness analysis estimated incremental cost per unit change on the Acne-QoL symptom subscale. Adjusted analysis included randomisation stratification variables (centre, baseline severity (investigator’s global assessment, IGA |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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