Tubulopapillary carcinoma of the mammary gland in a maned wolf (Chrysocyon brachyurus): histopathological and immunophenotypical analysis
| Autor: | C.O. Gamba, K.A. Damasceno, E. Ferreira, M.C.C. Malta, G.D. Cassali |
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| Jazyk: | English<br />Portuguese |
| Rok vydání: | 2011 |
| Předmět: | |
| Zdroj: | Arquivo Brasileiro de Medicina Veterinária e Zootecnia, Vol 63, Iss 6, Pp 1377-1381 (2011) |
| Druh dokumentu: | article |
| ISSN: | 1678-4162 0102-0935 |
| DOI: | 10.1590/S0102-09352011000600014 |
| Popis: | A maned female wolf (Chrysocyon brachyurus) showed nodules in the inguinal and left abdominal cranial mammary glands. The mammary gland was surgically excised, and microscopic analysis revealed epithelial cell proliferation in a tubular and papillary pattern; delicate fibrovascular stalks presenting numerous layers of moderately pleomorfic epithelial cells were observed. This histologic appearance was compatible with a diagnosis of mammary tubulopapillary carcinoma. The immunohistochemical profile revealed nuclear positivity for estrogen (70%) and progesterone (at least 90% of the neoplastic cells). The myoepithelium-associated with neoplastic cells lacked integrity, as evidenced by failed smooth muscle alpha actin reactivity in microinvasive areas. A low proliferation index was observed (3.4%). To the authors' knowledge, the present case represents the first finding of female tubulopapillary carcinoma in a mammary gland in this species. |
| Databáze: | Directory of Open Access Journals |
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