| Autor: |
Yunxia Zhang, Meng Zhang, Hongwei Yang, Haobo Li, Shuangshuang Ma, Linfeng Xi, Yishan Li, Xincheng Li, Zhihui Fu, Zhu Zhang, Shuai Zhang, Qian Gao, Qiang Huang, Jun Wan, Wanmu Xie, Jifeng Li, Peiran Yang, Zhenguo Zhai |
| Jazyk: |
angličtina |
| Rok vydání: |
2024 |
| Předmět: |
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| Zdroj: |
iScience, Vol 27, Iss 2, Pp 108930- (2024) |
| Druh dokumentu: |
article |
| ISSN: |
2589-0042 |
| DOI: |
10.1016/j.isci.2024.108930 |
| Popis: |
Summary: Determining novel biomarkers for early identification of chronic thromboembolic pulmonary hypertension (CTEPH) could improve patient outcomes. We used the isobaric tag for relative and absolute quantitation approach to compare the serum protein profiles between CTEPH patients and the controls. Bioinformatics analyses and ELISA were also performed. We identified three proteins including heparanase (HPSE), gelsolin (GSN), and secreted protein acidic and rich in cysteine (SPARC) had significant changes in CTEPH. The receiver operating characteristic curve analysis showed that the areas under the curve of HPSE in CTEPH diagnosis were 0.988. Furthermore, HPSE was correlated with multiple parameters of right ventricular function. HPSE concentrations were significantly higher in patients with a low TAPSE/sPAP ratio (≤0.31 mm/mmHg) (65.4 [60.5,68.0] vs. 59.9 [35.9,63.2] ng/mL, p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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