Microfluidic Device Directly Fabricated on Screen-Printed Electrodes for Ultrasensitive Electrochemical Sensing of PSA

Autor: Shouhui Chen, Zhihua Wang, Xinyuan Cui, Linlei Jiang, Yuee Zhi, Xianting Ding, Zhihong Nie, Pei Zhou, Daxiang Cui
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Zdroj: Nanoscale Research Letters, Vol 14, Iss 1, Pp 1-7 (2019)
Druh dokumentu: article
ISSN: 1931-7573
1556-276X
DOI: 10.1186/s11671-019-2857-6
Popis: Abstract How to fabricate scale low-cost microfluidic device for detection of biomarkers owns a great requirement. Herein, it is for the first time reported that a new microfluidic device based on bonding polydimethylsiloxane microfluidic channels onto the substrate of a screen-printed electrode with coating glass solution was fabricated for electrochemical sensing of prostate-specific antigen (PSA). Compared to traditional microfabrication processes, this method is simple, fast, low cost, and also suitable for mass production. The prepared screen-printed electrode-based microfluidic device (CASPE-MFD) was used for the detection of the PSA in human serum. The prepared CASPE-MFD had a detection limit of 0.84 pg/mL (25.8 fM) and a good linearity with PSA concentration ranging from 0.001 to 10 ng/mL, which showed a great promise platform toward the development of miniaturized, low-cost electrochemical microfluidic device for use in human health, environmental monitoring, and other applications.
Databáze: Directory of Open Access Journals
Externí odkaz: