The neuroprotective mechanism of lithium after ischaemic stroke

Autor: Beina Chen, Manman Zhang, Ming Ji, Dianjun Zhang, Binjie Chen, Wenliang Gong, Xinyu Li, Yuefei Zhou, Chengyi Dong, Gehua Wen, Xiaoni Zhan, Xiafang Wu, Huiya Yuan, Enyu Xu, Maosheng Xia, Alexei Verkhratsky, Baoman Li
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Communications Biology, Vol 5, Iss 1, Pp 1-14 (2022)
Druh dokumentu: article
ISSN: 2399-3642
DOI: 10.1038/s42003-022-03051-2
Popis: Using the MCAO stroke mouse model, Chen et al. identify pathways that underlie the neuroprotective properties of lithium by using inhibitors of AKT/GSK3β/β-catenin and AKT/FoxO3a/β-catenin signaling. They report that the inhibitors reverse the protective effects of lithium thus conclude that both pathways are key for lithium-mediated neuroprotection.
Databáze: Directory of Open Access Journals
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