The Assessment of the Usefulness of Selected Markers in the Diagnosis of Chronic Kidney Disease in Children
| Autor: | Agata Będzichowska, Katarzyna Jobs, Małgorzata Kloc, Anna Bujnowska, Bolesław Kalicki |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: | |
| Zdroj: | Biomarker Insights, Vol 16 (2021) |
| Druh dokumentu: | article |
| ISSN: | 1177-2719 11772719 |
| DOI: | 10.1177/11772719211011173 |
| Popis: | Introduction: The kidney deterioration, which starts in childhood often leads to end-stage renal failure in the future. Therefore, searching for an early, sensitive, and specific biomarkers became a paramount for chronic kidney disease diagnosis. The aim of this study was the assessment of markers: KIM-1, FGF-23, NAG, NGAL, and uromodulin for diagnosis of preclinical phase of the disease in children. Patients and methods: 59 children (15 boys, 44 girls from 6 months to 17 years old) with kidney disorders, which had clinical indications for renoscintigraphy, were included in the study. All patients were divided depending on the result of renoscintigraphy (renal scarring vs normal kidney picture) and depending on the level of estimated glomerular filtration rate (glomerular hyperfiltration vs normal filtration rate). The concentration of uromoduline, KIM-1, FGF-23, NAG, and NGAL in serum and of NGAL and uromoduline in urine were measured in all studied groups. Results: The children with glomerular hyperfiltration had a statistically significantly higher serum values of FGF-23 and NGAL than the children with normal filtration rate ( P |
| Databáze: | Directory of Open Access Journals |
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