| Autor: |
Morufu Oyedunsi Olayiwola, Adedapo Ismaila Alaje |
| Jazyk: |
angličtina |
| Rok vydání: |
2024 |
| Předmět: |
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| Zdroj: |
Franklin Open, Vol 7, Iss , Pp 100117- (2024) |
| Druh dokumentu: |
article |
| ISSN: |
2773-1863 |
| DOI: |
10.1016/j.fraope.2024.100117 |
| Popis: |
Studying viral infections within the host is crucial for understanding healthy cell responses and immunity. This research employed a reaction-diffusion Caputo fractional order model and a modified homotopy perturbation method to explore how immune cell memory and mobility affect the dynamic interactions of cytotoxic T-lymphocyte cells (CTLs), B-cell antibodies, uninfected monocytes, infected monocytes, and Dengue Virus (DENV) particle concentration within the host. The model guaranteed a positive solution, with the existence and uniqueness of the solution assured by the Banach fixed point theorem and a general stability supported by the Hyers-Ulam theorem. Sensitivity analysis highlighted that the DENV invasion rate speeds the spread of infected cells, while simulation results and fractional order analysis revealed that cell-mediated memory from past exposure will enhance the activation of CTLs and B-cell antibodies to strengthen immunity against dengue virus. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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