Anti‐dsDNA, anti‐nucleosome, anti‐C1q, and anti‐histone antibodies as markers of active lupus nephritis and systemic lupus erythematosus disease activity

Autor: Xiaoying Shang, Lisheng Ren, Guirong Sun, Teng Yu, Yuan Yao, Lin Wang, Fenghai Liu, Lijun Zhang, Xiaqin He, Mingjun Liu
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: Immunity, Inflammation and Disease, Vol 9, Iss 2, Pp 407-418 (2021)
Druh dokumentu: article
ISSN: 2050-4527
DOI: 10.1002/iid3.401
Popis: Abstract Introduction Previous studies of anti‐dsDNA, nucleosome (Nucl), histone (His), and C1q antibodies have revealed their clinical value in systemic lupus erythematosus (SLE). However, the correlation between four autoantibodies and SLE activity, lupus nephritis (LN) remains controversial, and data are insufficient on longitudinal monitoring. This study aimed at evaluating the value of these autoantibodies in active LN, and their performance on cross‐sectional evaluating and longitudinal monitoring of SLE disease activity. Methods Serum levels of four autoantibodies in 114 SLE patients, 219 other autoimmune disease patients (OAD), and 59 healthy controls were assayed by a quantitative immunoassay. Sera of 38 inpatients were obtained again after treatment. Results We found that serum levels of four autoantibodies were significantly higher in SLE than OAD patients (p .05). Conclusions Anti‐C1q, anti‐dsDNA, anti‐Nucl, and anti‐His perform well in diagnosing active LN and monitoring SLE disease activity. They could be indicators of active LN and SLE disease activity.
Databáze: Directory of Open Access Journals
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