| Autor: |
Ahmed I. Younes, Marwan M. Majeed, Moiz Vora, Maurice D. Richardson |
| Jazyk: |
angličtina |
| Rok vydání: |
2022 |
| Předmět: |
|
| Zdroj: |
Human Pathology Reports, Vol 30, Iss , Pp 300682- (2022) |
| Druh dokumentu: |
article |
| ISSN: |
2772-736X |
| DOI: |
10.1016/j.hpr.2022.300682 |
| Popis: |
Signet ring cell lymphoma is an exceedingly rare subtype of non-Hodgkin lymphoma that was originally thought to be a morphologic variant of follicular lymphoma. To date, 56 cases have been reported, with the majority occurring in lymph nodes and bone marrow. Herein, we report a case of a 37-year-old female who presented with a left inguinal mass and high suspicion of lymphoma that was rendered on MRI. A successful ultrasound-guided core biopsy was performed. Pathologic examination revealed a diffuse large B-cell lymphoma (DLBCL) with unique signet ring histology and post-germinal center phenotype. In-situ hybridization showed an isolated BCL-6 gene rearrangement and confirmed the absence of a double-hit phenotype. This case would be situated as the second case of activated B-cell (ABC) signet ring lymphoma and the first case to arise in this anatomic location. The patient recently initiated therapy with a standard six-cycle regimen of R-CHOP (rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone). |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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