Docking studies of some pyrazole containing compounds in the cyclooxygenase-2 active site
| Autor: | Savić Jelena, Antonijević Marija, Crevar Milkica, Brborić Jasmina |
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| Jazyk: | srbština |
| Rok vydání: | 2023 |
| Předmět: | |
| Zdroj: | Arhiv za farmaciju, Vol 73, Iss 3, Pp 205-215 (2023) |
| Druh dokumentu: | article |
| ISSN: | 0004-1963 2217-8767 |
| Popis: | Whereas nonselective nonsteroidal anti-inflammatory drugs, such as aspirin, ibuprofen and diclofenac, inhibit both cyclooxygenase-1 and cyclooxigenase-2 enzymes, selective inhibitors target cyclooxygenase-2, which is overexpressed in inflammation, but also in cancer, atherosclerosis, Alzheimer's disease, and Parkinson's disease. Potential cardiovascular and hepatic side effects of cyclooxygenase-2 inhibitors have limited their use. The development of selective and safe cyclooxygenase-2 inhibitors remains a high priority in drug discovery. Based on the structure of previously investigated newly synthesized b-hydroxy-b-arylpropanoic acids, two groups of compounds were designed: analogs in which one of the benzene rings was replaced by a pyrazole, while the carboxyl group was retained, and amides of b-hydroxy-b-arylpropanoic acids with pyrazole. The compounds were docked into the 3D structure of the catalytic site of the enzyme cyclooxygenase-2 using AutoDock Vina 1.2.0. and the obtained interactions were compared with the interactions of celecoxib, a selective inhibitor. The amides had lower binding energies than the designed acids, which makes them attractive target compounds for synthesis and further examination. |
| Databáze: | Directory of Open Access Journals |
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