Prephase rituximab/prednisone therapy and aging-related, proinflammatory cytokine milieu in older, vulnerable patients with newly diagnosed diffuse large B-cell lymphoma
| Autor: | Richard J. Lin, Colette N. Owens, Esther Drill, Augustine Iannotta, Mayan Oliveros, Dylan L. Schick, Ariela Noy, John F. Gerecitano, Pamela R. Drullinsky, Philip C. Caron, Anita Kumar, Matthew J. Matasar, Craig Moskowitz, Beatriz Korc-Grodzicki, Andrew D. Zelenetz, Gilles A. Salles, Paul A. Hamlin |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: | |
| Zdroj: | Haematologica, Vol 107, Iss 5 (2021) |
| Druh dokumentu: | article |
| ISSN: | 0390-6078 1592-8721 |
| DOI: | 10.3324/haematol.2021.278719 |
| Popis: | Diffuse large B-cell lymphoma (DLBCL) predominantly affects older adults with suboptimal therapeutic outcomes due to increased treatment-related mortality and toxicities in vulnerable patients, clinically defined by geriatric impairments such as functional limitation, multimorbidity, or cognitive deficits. In this prospective pilot study, we evaluated a rituximab/prednisone prephase treatment strategy in 33 older, vulnerable patients with newly diagnosed DLBCL, defined by either age ≥70 years or age 60-70 years with Karnofsky performance scale (KPS) |
| Databáze: | Directory of Open Access Journals |
| Externí odkaz: |
|