| Autor: |
Martina Severa, Daniela Ricci, Marilena Paola Etna, Marzia Facchini, Simona Puzelli, Giorgio Fedele, Egidio Iorio, Giada Cairo, Sara Castrechini, Valentina Ungari, Marco Iannetta, Pasqualina Leone, Mattea Chirico, Maria Elena Pisanu, Barbara Bottazzi, Livia Benedetti, Michela Sali, Remo Bartolomucci, Stefano Balducci, Cecilia Garlanda, Paola Stefanelli, Antonietta Spadea, Anna Teresa Palamara, Eliana Marina Coccia |
| Jazyk: |
angličtina |
| Rok vydání: |
2024 |
| Předmět: |
|
| Zdroj: |
Vaccines, Vol 12, Iss 9, p 1050 (2024) |
| Druh dokumentu: |
article |
| ISSN: |
2076-393X |
| DOI: |
10.3390/vaccines12091050 |
| Popis: |
In this pilot study, a multi-parametric analysis comparing immune responses in sera of adult healthy subjects (HS) or people with type 2 diabetes mellitus (T2D) undergoing the single or simultaneous administration of mRNA-based COVID-19 and cellular quadrivalent inactivated influenza vaccines was conducted. While SARS-CoV-2 antibodies remains comparable, influenza antibody titers and seroconversion were significantly higher upon simultaneous vaccination. Magnitude of anti-influenza humoral response closely correlated with an early innate immune signature, previously described for the COVID-19 vaccine, composed of IL-15, IL-6, TNF-α, IFN-γ, CXCL-10 and here extended also to acute-phase protein Pentraxin 3. People with T2D receiving simultaneous vaccination showed a protective response comparable to HS correlating with the early induction of IFN-γ/CXCL10 and a significant reduction of the circulating glucose level due to increased oxidation of glucose digestion and consumption. These data, although preliminary and in-need of validation in larger cohorts, might be exploited to optimize future vaccination in people with chronic disorders, including diabetes. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
|
