Cognition and biomarkers of oxidative stress in obstructive sleep apnea
| Autor: | Leticia Viana Sales, Veralice Meireles Sales de Bruin, Vania D'Almeida, Sabine Pompéia, Orlando Francisco Amodeo Bueno, Sérgio Tufik, Lia Bittencourt |
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| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: | |
| Zdroj: | Clinics, Vol 68, Iss 4, Pp 449-455 (2013) |
| Druh dokumentu: | article |
| ISSN: | 1807-5932 1980-5322 |
| Popis: | OBJECTIVES: The aim of this study was to investigate neuropsychological performance and biomarkers of oxidative stress in patients with obstructive sleep apnea and the relationships between these factors. METHODS: This was an observational, cross-sectional study of 14 patients (36.0±6.5 years old) with obstructive sleep apnea and 13 controls (37.3±6.9 years old). All of the participants were clinically evaluated and underwent full-night polysomnography as well as neuropsychological tests. Blood samples were used to assay superoxide dismutase, catalase, glutathione and homocysteine, as well as vitamins E, C, B11 and B12. RESULTS: The patients performed poorly relative to the controls on several neuropsychological tests, such as the attention test and tests of long-term memory and working memory/executive function. They also had lower levels of vitamin E (p |
| Databáze: | Directory of Open Access Journals |
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