Apoptosis induced by mercuric chloride is associated with upregulation of PERK-ATF4-CHOP pathway in chicken embryonic kidney cells

Autor: Yan Ma, Yizhen Shi, Xiaoting Zou, Qiujue Wu, Jianping Wang
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Zdroj: Poultry Science, Vol 99, Iss 11, Pp 5802-5813 (2020)
Druh dokumentu: article
ISSN: 0032-5791
DOI: 10.1016/j.psj.2020.06.084
Popis: Mercuric chloride (HgCl2) is a serious environmental toxicant. So far, the toxicity mechanism of HgCl2 in chicken embryonic kidney (CEK) cells is not still fully understood. In this study, the possible molecular mechanisms of HgCl2 on apoptosis of CEK cells were investigated. Results showed that the cell morphology changed, and cell viability was significantly decreased (P
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