| Autor: |
Chee Fu Yung, Nina Le Bert, Kai Qian Kam, Seyed Ehsan Saffari, Chee Wah Tan, Yun Yan Mah, Jinyan Zhang, Aileen Ying-Yan Yeoh, Feng Zhu, Smrithi Hariharaputran, Chia Yin Chong, Antonio Bertoletti, Linfa Wang |
| Jazyk: |
angličtina |
| Rok vydání: |
2023 |
| Předmět: |
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| Zdroj: |
Scientific Reports, Vol 13, Iss 1, Pp 1-8 (2023) |
| Druh dokumentu: |
article |
| ISSN: |
2045-2322 |
| DOI: |
10.1038/s41598-023-44565-x |
| Popis: |
Abstract There is little information on BNT162b2 vaccine-induced variant-specific immunogenicity, safety data and dynamics of breakthrough infections in pediatric populations. We addressed these questions using a prospective two dose BNT162b2 (10 mcg) vaccination cohort study of healthy children 5–11 years in Singapore. Follow up included blood samples at scheduled visits, daily vaccination symptom diary and confirmation of SARS-CoV-2 infection. Surrogate virus neutralization test (sVNT) and spike-specific T cell responses against SARS-CoV-2 variants were performed. The mean age of 127 participants was 8.27 years (SD 1.95) and 51.2% were males. The median sVNT level against original variant after 1 dose and 2 dose vaccination was 61.4% and 95.1% respectively (p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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